icobrain ms

objectively track disease progression in individual multiple sclerosis patients

How to interpret your icobrain ms report

Page 1: Evolution of white matter abnormalities

info1 qc1 visualResults1 lesionVolumes1 regionalLesions1 softwareVersion1
  • INFO

    MRI dates = dates of the MRI scans on which the report is based. When only one MRI exam is available, a baseline report is created which reports volumes but no volume changes.

  • QC

    Status of semi automated quality control (Approved / Approved with remarks / Rejected / Unusable) and remarks on the quality of the original images and the segmentation.

  • VISUAL RESULTS

    Color-coded segmentation of FLAIR white matter (WM) hyperintensities

    • Periventricular (yellow)
    • Juxtacortical (red)
    • Infratentorial (green)
    • Deep white matter (blue)

    This segmentation is also available in DICOM format.

  • WHITE MATTER ABNORMALITIES

    FLAIR WM hyperintensities and T1 WM hypointensities are always repor ted.
    For post-C T1 sequences, the T1 WM hyperintensities are also reported

    Volume change = total difference in volume compared to the previous scan
    New + Enlarging – Shrinking (includes disappearing) = Volume change

  • Regional FLAIR WM hyperintensities volume

    The bar chart shows the volume at time point 1 (t1), time point 2 (t2) and the change (△) for each location (periventricular, juxtacortical, infratentorial, and deep white matter). Total, new, enlarging and shrinking volumes are indicated for each location. New + Enlarging - Shrinking = △

  • SOFTWARE VERSION & CONTACT INFORMATION

    The icobrain software version and its approval for clinical practice.

Page 2: Brain volume change

info2 visualResults2 brainVolumes2 populationGraph softwareVersion2
  • INFO

    MRI dates = dates of the MRI scans on which the report is based. When only one MRI exam is available, a baseline report is created which reports volumes but no volume changes.

  • VISUAL RESULTS

    T1 white matter (WM) hypointensities (red) and gray matter (blue) segmentation.
    This segmentation is also available in DICOM format.

  • BRAIN VOLUMES

    Whole brain and gray matter volumes are corrected for head size. The normal range and normative percentiles serve as a reference based on healthy controls.
    Annualized volume change describes the percentage of brain volume change per year compared to the previous scan.
    The normal annualized volume change represents the average expected annual volume change for a healthy age- and gender-matched person.

  • Population graph

    The graph shows the age- and gender-matched average and normal range for the whole brain (left) and gray matter (right) volume of healthy people.The current (black) and previous (white) time points are marked with an ‘x’.
    The error bars are computed from the pooled results of several test-retest experiments.They represent the interval in which the differences between test- and retest results can be found with 90% confidence.

  • SOFTWARE VERSION & CONTACT INFORMATION

    The icobrain software version and its approval for clinical practice.

Single time point segmentation interpretation

Hover over the segmentations

Black holes
Gray matter
Juxtacortical
Deep white matter
Periventricular
Infratentorial

Longitudinal segmentation interpretation

NEW

ENLARGING

STABLE

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